Bioinformatics

Laboratory of Systems Biology

Published date: 
Feb 29, 2016
Research Services: 
  • Standard and advanced microarray data pre-processing techniques, including quality control analysis, normalization, batch effect removal, eliminating unspecific probes, performing custom annotation and using custom chip definition (CDF) files for more accurate expression evaluation.
  • Professional analysis of expression data: finding differentially expressed genes with linear models and eBayes methods, gene ontology terms enrichment analysis with modern tools (GSEA, EnrichR), cluster analysis and classification of samples, gene regulatory networks reconstruction (Bayesian inference and information theory approaches), visualization (PCA, heatmaps, boxplots etc) and plots creating with ggplot2 R library.

Laboratory Protein Biosynthesis

Published date: 
Mar 29, 2016
Research Services: 
  • Bioinformatic analysis of a protein of interest.
  • Modelling and analysis of protein structures, molecular docking.
  • Production of the proteins in bacteria and baculovirus systems, site-directed mutagenesis of proteins.
  • Isolation of preparative quantities of fully post-translationally modified oncogenic isoform eEF1A2 of mammalian translation elongation factor and its non-oncogenic paralogue eEF1A1.

Laboratory of Biosynthesis of Nucleic Acids

Published date: 
Feb 12, 2015
Research Services: 

Bioinformatics

  • Analysis of differential gene expression (DGE) using publicly available databases;
  • Microarray and next generation sequencing data analysis;
  • Gene expression clustering;
  • Kohonen’s maps
  • Gene and protein sequence analysis and alignment;
  • Phylogenetic and evolutionary studies;
  • Homology modeling;
  • Anti-sense oligos and primers design.

Other services

Laboratory of Computer Modeling

Published date: 
Jan 30, 2015
Research Services: 
  • Virtual high-throughput screening using structure-based (molecular docking) and ligand-based (QSAR, pharmacophore modeling) approaches;
  • Identification and analysis of binding sites;
  • Structure-activity relationship (SAR) analysis;
  • Computational studies of drug-receptor interactions;
  • Hit identification and optimization;
  • Hit to lead optimization;
  • In silico ADME predictions;
  • Molecular dynamics of proteins, nucleic acids, extra large heterogeneous systems;
  • Design of target-focused compound libraries with high affinity to the molecular targets (our compound collection contains about 200,000 organic compounds which are immediately available for screening).